Why the study?
Does enalaprilat improve baroreflex control of renal and total noradrenaline spillover in rabbits with doxorubicin-induced heart failure?
Population
17 conscious rabbits
Comparison
Enalaprilat infusion vs Saline infusion
Design
Preclinical
Follow-up
6 weeks
Authors
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Should not yet change practice; supports and extends RAS contribution to baroreflex impairment in experimental heart failure.
Does enalaprilat improve baroreflex control of renal and total noradrenaline spillover in rabbits with doxorubicin-induced heart failure?
Enalaprilat enhances baroreflex control of noradrenaline spillover in a rabbit model of heart failure, highlighting the role of the renin-angiotensin system in autonomic dysfunction.
Noshiro et al. (1993) studied this question.
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