January 2, 2004Nucleic Acids ResearchOpen Access

Modifications of the 3'-UTR stem-loop of infectious bursal disease virus are allowed without influencing replication or virulence

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Structured PICO

Population

Infectious bursal disease virus (IBDV) in vitro (cell culture) and in vivo (chickens, natural host)

Intervention

Mutagenesis of the 3'-UTR stem-loop structure of the B-segment

Comparator

Wild-type virus

Outcome

Replication kinetics and virulence

The stem-loop structure, rather than the primary sequence, is the functional determinant in the 3'-UTRs of IBDV for replication and virulence.

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Supports RNA structure over sequence as IBDV virulence determinant; leaves open generalization beyond this avian model.

Hein J. Boot (2004) studied this question.

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