Population
Transfected BHK-21 cells
Comparison
HCV genotype 1b variant IRES elements with… vs Prototypic HCV-1b IRES (wild-type)
Design
Preclinical
Authors
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May inform HCV antiviral design targeting IRES structure; leaves open in vivo validation and clinical translation.
Both the primary sequence and base pairing within stem-loop IIIc are critical for HCV IRES function, and defective mutants cannot be complemented in trans.
Tang et al. (1999) studied this question.
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