What does this research mean for the field?

Alpha tropomyosin in frog and rabbit skeletal and cardiac muscle is specifically phosphorylated at a single, unique site (serine-283), which distinguishes it from beta tropomyosin and is predicted to affect the stability of tropomyosin polymers. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

August 1, 1978Proceedings of the National Academy of SciencesOpen Access

Specific phosphorylation at serine-283 of alpha tropomyosin from frog skeletal and rabbit skeletal and cardiac muscle.

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Population

Tropomyosin extracted from frog leg muscle, rabbit skeletal muscle, and rabbit cardiac muscle

Design

Preclinical

Authors

AMAlan S. MakQueen's University LSLawrence B. SmillieMedical Council of Canada MBMichael BárányUniversity of Edinburgh

Discussion

Member takes

Implication

May modulate tropomyosin polymer stability in striated muscle; leaves open relevance to human cardiac function.

Structured PICO

Population

Tropomyosin extracted from frog leg muscle, rabbit skeletal muscle, and rabbit cardiac muscle

Intervention

[32P]orthophosphate injection (in frogs) and fractionation of tropomyosin

Outcome

Identification of the phosphorylation site on alpha tropomyosinsurrogate

The study identifies serine-283 as a specific phosphorylation site on alpha tropomyosin in frog and rabbit muscle, which may influence the stability of tropomyosin polymers.

Cite This Study

Mak et al. (1978) studied this question.

synapsesocial.com/papers/6a1bf2fe27b545b111a93f06 https://doi.org/10.1073/pnas.75.8.3588

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August 1, 1978Proceedings of the National Academy of SciencesOpen Access

Specific phosphorylation at serine-283 of alpha tropomyosin from frog skeletal and rabbit skeletal and cardiac muscle.

View Full Paper

Ask AI

Bookmark

Population

Tropomyosin extracted from frog leg muscle, rabbit skeletal muscle, and rabbit cardiac muscle

Design

Preclinical

Authors

AMAlan S. MakQueen's University LSLawrence B. SmillieMedical Council of Canada MBMichael BárányUniversity of Edinburgh

Discussion

Member takes

Implication

May modulate tropomyosin polymer stability in striated muscle; leaves open relevance to human cardiac function.

Structured PICO

Population

Tropomyosin extracted from frog leg muscle, rabbit skeletal muscle, and rabbit cardiac muscle

Intervention

[32P]orthophosphate injection (in frogs) and fractionation of tropomyosin

Outcome

Identification of the phosphorylation site on alpha tropomyosinsurrogate

The study identifies serine-283 as a specific phosphorylation site on alpha tropomyosin in frog and rabbit muscle, which may influence the stability of tropomyosin polymers.

Cite This Study

Mak et al. (1978) studied this question.

synapsesocial.com/papers/6a1bf2fe27b545b111a93f06 https://doi.org/10.1073/pnas.75.8.3588

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