Why the study?
Does ketanserin provide vascular protection against pathologies resulting from platelet-vessel wall interactions?
Does ketanserin provide vascular protection against pathologies resulting from platelet-vessel wall interactions?
Ketanserin is hypothesized to offer vascular protection by antagonizing 5-HT2 receptors, potentially preventing thrombus formation and vasospasms.
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Ketanserin may support vascular protection via 5-HT2 blockade; leaves open clinical efficacy pending prospective trials.
Based upon experimental data, we advance the hypothesis that ketanserin, a 5-HT(2) serotonergic receptor antagonist, may provide protection against pathologies resulting from platelet-vessel wall interactions such as myointimal proliferation, vasospasms and thrombus formation. Clinical data support the possibility that such a vascular protection is operational also in man.
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Clerck et al. (1991) studied this question.
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