Why the study?
Does left coronary occlusion change the content of purine nucleosides in canine myocardium?
Does left coronary occlusion change the content of purine nucleosides in canine myocardium?
Coronary occlusion rapidly increases adenosine and inosine content in canine myocardium within 15 seconds.
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Rapid adenosine rise in canine ischemia warrants caution extrapolating to humans; leaves open clinical relevance.
The use of a sensitive double-beam spectrophotometer and modifications in enzymatic assay techniques permitted the measurement of adenine nucleosides in extracts of canine left ventricle. In hearts not subjected to left coronary occlusion, adenosine content averaged 0.32 ± 0.04 ( SE ) nmole/g, increasing to an average of 1.82 ± 0.21 ( SE ) nmole/g after 15 seconds of coronary occlusion. The myocardial content of inosine plus hypoxanthine was 1.07 ± 0.21 ( SE ) nmole/g without coronary occlusion, rising to 1.98 ± 0.24 ( SE ) nmole/g after 15 seconds of coronary occlusion. Unlike the myocardial content of adenosine and inosine, the myocardial content of hypoxanthine did not appear to change during coronary occlusion.
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Ray A. Olsson (1970) studied this question.
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