Key result
Polio virus infection and actinomycin-D treatment in HeLa cells induce a new class of polysomes containing up to 60 ribosomes, compared to normal polysomes containing over 40 ribosomes.
Answers are grounded in this paper and cite their sources.
Polio virus infection induces a new class of larger polysomes in HeLa cells, suggesting a mechanism for protein synthesis with polycistronic RNA.
HeLa cells normally contain a distribution of polysome sizes, and the largest polysomes contain over 40 ribosomes. After infection with polio virus and actinomycin-D treatment, a new class of polio-induced polysomes are found, some of which contain up to 60 ribosomes. Examinaton of these polysomes suggests a mechanism for protein synthesis with this polycistronic RNA.
No takes yet. Share an insight, caveat, or question.
Rich et al. (1963) studied this question. Polio virus infection and actinomycin-D treatment in HeLa cells induce a new class of polysomes containing up to 60 ribosomes, compared to normal polysomes containing over 40 ribosomes.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: