Key result
Fosinopril effectively lowered systolic blood pressure in hypertensive children, demonstrating a net withdrawal effect of 3.7 mm Hg compared to placebo (P=0.013).
Why the study?
Does fosinopril reduce trough seated systolic blood pressure in children aged 6 to 16 years with hypertension?
Population
Children aged 6 to 16 years with hypertension or high-normal blood pressure with an associated medical…
Comparison
Fosinopril at low, medium, or high doses. vs Placebo.
Design
RCT, double-blind
Follow-up
Up to 58 weeks
Authors
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Supports incorporating fosinopril into pediatric hypertension management; extends randomized evidence to children aged 6-16.
RCT
Double-blind
Yes
Does fosinopril reduce trough seated systolic blood pressure in children aged 6 to 16 years with hypertension?
Mean Difference: 3.7
Absolute Event Rate: 1.5% vs 5.2%
p-value: p=0.013
Fosinopril is safe and effective for lowering blood pressure in hypertensive children, with a recommended starting dose of ≤0.1 mg/kg due to higher sensitivity compared to adults.
Li et al. (2004) conducted an RCT in Hypertension or high-normal blood pressure. Fosinopril vs. Placebo was evaluated on Trough seated systolic blood pressure (MD 3.7, p=0.013). Fosinopril effectively lowered systolic blood pressure in hypertensive children, demonstrating a net withdrawal effect of 3.7 mm Hg compared to placebo (P=0.013).
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