Key result
Myocardial infarction reduces carotid wall shear stress by ~44% vs sham in rats.
Why the study?
Normal and shear stress changes in peripheral artery walls are important for understanding the progression of myocardial infarction-induced heart failure, but remain to be investigated.
Does myocardial infarction impair wall mechanics and hemodynamics in peripheral arteries in a rat model?
Does myocardial infarction impair wall mechanics and hemodynamics in peripheral arteries in a rat model?
Answers are grounded in this paper and cite their sources.
Myocardial infarction induces significant increases in peripheral artery wall stiffness and deteriorates hemodynamic parameters like wall shear stress, contributing to the understanding of MI-induced heart failure progression.
Myocardial infarction (MI) impaired both cardiac functions and peripheral arteries. The changes in normal and shear stresses in the peripheral artery wall are of importance for understanding the progression of MI-induced heart failure (HF). The aim of the study is to investigate the corresponding changes of normal and shear stresses. The coronary artery ligation was used to induce the MI in Wistar rats. The analysis of wall mechanics and hemodynamics was performed based on in vivo and in vitro measurements. Myocardial infarction increased wall stiffness in elastic carotid and muscular femoral arteries significantly albeit different changes occurred between the two vessels from 3 to 6 weeks postoperatively. Moreover, the hemodynamic analysis showed the gradually deteriorated wall shear stress, oscillatory shear index and relative residence time in the two arteries. This study probably shed light on understanding the interaction between abnormal systemic circulation and peripheral mechanics and hemodynamics during the development of MI-induced HF.
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Xue et al. (2023) studied Myocardial infarction (n=20). Myocardial infarction (LAD ligation) vs. Sham operation was evaluated on Time-averaged wall shear stress (TAWSS) in carotid artery at 6 weeks (dynes/cm2) (p=<0.05). Myocardial infarction significantly impaired peripheral artery hemodynamics, reducing time-averaged wall shear stress in the carotid artery to 3.87 dynes/cm2 compared to 6.90 dynes/cm2 in sham-operated rats at 6 weeks.
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