Why the study?
Does nitric oxide manipulation alter local cerebral blood flow differently in spontaneously hypertensive rats compared to normotensive rats?
Population
Conscious spontaneously hypertensive (SHR) and WKY rats
Comparison
L-NAME, 7-NI, or SIN-1 administered 20 min… vs Saline (i.v.)
Design
Preclinical
Follow-up
20 minutes
Authors
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Hypothesis-generating for impaired cerebrovascular NO signaling in hypertension; clinical translation requires prospective human studies.
Does nitric oxide manipulation alter local cerebral blood flow differently in spontaneously hypertensive rats compared to normotensive rats?
The study demonstrates that NO-dependent vasodilator capacity is reduced in the cerebrovasculature of spontaneously hypertensive rats, suggesting an upregulation of the neuronal NO system.
Fouyas et al. (1997) studied this question.
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