Key result
Angiotensin II infusion in mice promoted region-specific aortic medial hypertrophy and hyperplasia, with ascending aortic hyperplasia dependent on the inhibitor of differentiation 3 (Id3).
Angiotensin II promotes region-specific smooth muscle cell hyperplasia in the ascending aorta through an Id3-dependent oxidant mechanism.
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These murine data should not change practice; leaves open Id3 as a therapeutic target in human aortic disease.
Owens et al. (2009) studied Aortic medial expansion. Angiotensin II vs. Norepinephrine or genetic deficiencies (AT1a, p47phox, Id3) was evaluated on Aortic medial expansion and smooth muscle cell hyperplasia. Angiotensin II infusion in mice promoted region-specific aortic medial hypertrophy and hyperplasia, with ascending aortic hyperplasia dependent on the inhibitor of differentiation 3 (Id3).
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