Key result
Overexpression of a novel angiotensin II type 1 receptor-associated protein induced cellular hypertrophy in cultured rat vascular smooth muscle and renal proximal tubular cells.
Population
Cultured rat vascular smooth muscle and renal proximal tubular cells, and human embryonic kidney cells
Comparison
Overexpression of a novel angiotensin II type 1… vs Cells expressing the novel gene in the antisense…
Design
Preclinical
Authors
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Should not yet change practice; hypothesis-generating for angiotensin II type 1 receptor-associated protein in vascular and renal hypertrophy.
A novel angiotensin II type 1 receptor-associated protein mediates angiotensin II-induced cellular hypertrophy in vascular smooth muscle and renal cells, providing a potential molecular mechanism for early morphological changes in heart and renal failure.
Guo et al. (2004) studied Cellular hypertrophy. Overexpression of novel angiotensin II type 1 receptor-associated protein vs. Antisense orientation and dominant negative mutant was evaluated on Cellular hypertrophy (protein synthesis and relative cell size). Overexpression of a novel angiotensin II type 1 receptor-associated protein induced cellular hypertrophy in cultured rat vascular smooth muscle and renal proximal tubular cells.
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