Key result
Higher SYNTAX scores were associated with an increased risk of major adverse cardiac and cerebro-vascular events (HR 1.100) in Chinese patients undergoing percutaneous coronary intervention.
Why the study?
Studies comparing the prognostic value of the SYNTAX score and clinical SYNTAX score in the Chinese population have been sparse.
Does the clinical SYNTAX score improve risk stratification for clinical outcomes compared to the SYNTAX score in Chinese patients undergoing PCI?
Cohort (n=547)
No
Does the clinical SYNTAX score improve risk stratification for clinical outcomes compared to the SYNTAX score in Chinese patients undergoing PCI?
Both the SYNTAX score and clinical SYNTAX score are capable of risk stratification for clinical outcomes in Chinese patients undergoing PCI, with the clinical SYNTAX score showing a slight advantage for predicting all-cause death.
Answers are grounded in this paper and cite their sources.
May aid MACCE risk stratification with SYNTAX score in Chinese PCI patients; extends validation to this cohort but leaves clinical adoption open.
BACKGROUND: Previous studies have validated the capability of SYNTAX score (SS) and clinical SYNTAX score (CSS) in the prediction of clinical outcomes in patients who have undergone PCI; however, studies on comparison of these two scoring systems in Chinese population have been sparse. METHODS: To study the ability of SS and CSS in prediction of clinical outcomes of Chinese patients underwent percutaneous coronary intervention (PCI). We retrospectively calculated SS and CSS for 547 Chinese patients from a single center who underwent PCI. Patients were stratified into tertiles according to their SS and CSS. We compared the 2-year clinical outcomes in these patients stratified separately by SS and CSS tertiles. RESULTS: (p < 0.0001). The Cox multivariable analysis showed that the SS and CSS were both strong independent predictors for MACCE [1.100 (1.069-1.133), 1.017 (1.010-1.025), both p < 0.0001]. The receiver operating characteristic (ROC) curves showed the areas-under-the-curves for all-cause death by CSS was slightly larger comparing to SS but not significantly (AUC SS, 0.64; AUC CSS, 0.71; p = 0.23). CONCLUSION: We concluded that both the SS and CSS were capable of risk stratification of clinical outcomes in all-comers population as well as in low and moderate risk Chinese patients undergoing PCI with CSS showing slightly better advantage.
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Li et al. (2021) conducted a cohort in Coronary artery disease (n=547). SYNTAX score (SS) vs. Low SYNTAX score was evaluated on Major adverse cardiac and cerebro-vascular events (MACCE) (HR 1.100, 95% CI 1.069-1.133, p=<0.0001). Higher SYNTAX scores were associated with an increased risk of major adverse cardiac and cerebro-vascular events (HR 1.100) in Chinese patients undergoing percutaneous coronary intervention.
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