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May 17, 2010Journal of the Renin-Angiotensin-Aldosterone SystemOpen Access

Association of ACE I/D polymorphism in Tunisian patients with dilated cardiomyopathy

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Why the study?

Is the ACE I/D polymorphism associated with an increased risk of dilated cardiomyopathy in a Tunisian population?

Population

76 patients with dilated cardiomyopathy and 151 ethnically, age- and gender-matched controls from a Tunisian…

Comparison

Angiotensin-converting enzyme I/D polymorphism vs ACE ID and II genotypes / I allele

Design

Case-control

Authors

SZSinda Zarrouk‐MahjoubTunis UniversitySMSounira MehriUniversity of MonastirRBRafik BousaadaHôpital La Rabta

Discussion

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Implication

DD genotype may raise DCM risk in Tunisians; hypothesis-generating and requires validation before clinical use.

Structured PICO

Is the ACE I/D polymorphism associated with an increased risk of dilated cardiomyopathy in a Tunisian population?

P
Population
76 patients with dilated cardiomyopathy and 151 ethnically, age- and gender-matched controls from a Tunisian population
I
Intervention
Angiotensin-converting enzyme (ACE) I/D polymorphism (DD genotype and D allele)
C
Comparator
ACE ID and II genotypes / I allele
O
Outcome
Risk of dilated cardiomyopathysurrogate

The ACE DD genotype and D allele are associated with an increased risk of dilated cardiomyopathy in the Tunisian population but do not affect cardiac phenotype severity.

Cite This Study

Zarrouk‐Mahjoub et al. (2010) studied this question.

synapsesocial.com/papers/6a242fffb7e293e61ca666achttps://doi.org/10.1177/1470320310368874
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Also Consider

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  2. 2PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidyl carboxypeptidase 1)1992 · 1,250 citations
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  4. 4Effects of Angiotensin-Converting Enzyme Inhibition on Angiotensin and Bradykinin Peptides in Rats with Myocardial Infarction1996 · 44 citations
  5. 5Localization of angiotensin converting enzyme in rat heart.1991 · 204 citations