Key result
UHF-ECG dyssynchrony predicts CRT response better than conventional ECG, yielding ~2% higher odds per ms.
Why the study?
Approximately one-third of heart failure patients fail to respond to biventricular pacing when selection relies on QRS duration and morphology, prompting investigation into whether UHF-ECG better predicts response.
Does UHF-ECG-derived ventricular dyssynchrony better predict response to cardiac resynchronization therapy than conventional ECG parameters in heart failure patients?
Cohort (n=114)
No
Does UHF-ECG-derived ventricular dyssynchrony better predict response to cardiac resynchronization therapy than conventional ECG parameters in heart failure patients?
Odds Ratio: 1.02
p-value: p=0.04
UHF-ECG-derived ventricular dyssynchrony (e-DYS) is a superior predictor of response to biventricular pacing compared to conventional QRS duration and morphology.
No takes yet. Share an insight, caveat, or question.
Hypothesis-generating in small Level 5 cohort; leaves open validation before any clinical adoption.
Leinveber et al. (2026) conducted a cohort in Heart failure (n=114). UHF-ECG-derived ventricular electrical dyssynchrony (e-DYS) vs. Conventional ECG parameters (QRS duration and morphology) was evaluated on Cardiac resynchronization therapy (CRT) response (OR 1.02 per ms, p=0.04). UHF-ECG-derived ventricular dyssynchrony independently predicted response to CRT (OR 1.02 per ms; P=0.04) more accurately than conventional ECG parameters.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: