Key result
Definitive treatment after balloon aortic valvuloplasty was associated with significantly lower two-year mortality compared to no definitive treatment (20.0% vs. 84.6%; p=0.005).
Why the study?
Does balloon aortic valvuloplasty (BAV) improve hemodynamics and serve as an effective bridge to definitive therapy or palliative care in patients with severe aortic stenosis?
Cohort (n=23)
No
Does balloon aortic valvuloplasty (BAV) improve hemodynamics and serve as an effective bridge to definitive therapy or palliative care in patients with severe aortic stenosis?
Absolute Event Rate: 20% vs 84.6%
p-value: p=0.005
Balloon aortic valvuloplasty effectively reduces transvalvular gradients and serves as a viable bridge to definitive therapy (TAVI or SAVR), which is associated with significantly improved survival compared to BAV alone.
BAV may relieve gradients acutely in selected patients; leaves open its role as bridge to definitive therapy in the TAVI era.
INTRODUCTION: Percutaneous balloon aortic valvuloplasty (BAV) has been limited by the risk of complications and restenosis. However, growing use of transcatheter aortic valve implantation (TAVI) has revived interest in this technique. We analyzed the current indications for BAV and outcomes in a single center. METHODS: Acute results and long-term outcomes were analyzed in a retrospective single-center registry of patients undergoing BAV between January 2013 and January 2016. RESULTS: Twenty-three patients underwent BAV, 56.5% male, mean age 78±7 years. Indications were severe aortic stenosis and decompensated heart failure (n=5), urgent non-cardiac surgery (n=8), or bridge to definitive treatment (n=10). Peak invasive gradient decreased from a median of 54.0±19.0 mmHg to 28.5±13.8 mmHg (p=0.002). Complications included one ischemic stroke, one lower limb ischemia and one femoral pseudoaneurysm requiring surgery. During a mean follow-up of 11±10 months, eight patients underwent TAVI and two underwent surgical aortic valve replacement. Thirteen patients died, nine of non-cardiovascular causes. On Kaplan-Meier analysis mortality was significantly lower among patients undergoing definitive treatment (20.0% vs. 84.6% at two-year follow-up; p=0.005). CONCLUSION: BAV should be considered for selected patients with temporary contraindications to definitive therapy or as palliative therapy.
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Francisco et al. (2017) conducted a cohort in Severe aortic stenosis (n=23). Definitive treatment after balloon aortic valvuloplasty vs. No definitive treatment was evaluated on Mortality (p=0.005). Definitive treatment after balloon aortic valvuloplasty was associated with significantly lower two-year mortality compared to no definitive treatment (20.0% vs. 84.6%; p=0.005).
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