Key result
Transfection with large amounts of engineered quasi-infectious poliovirus RNAs yielded revertant clones with diverse genetic changes, highlighting the importance of an oligopyrimidine-AUG tandem.
Population
Poliovirus RNA species with nucleotides 564 to 571 deleted or with a secondary structure domain replaced by…
Design
Preclinical
Authors
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May inform antiviral targeting of viral translation; leaves open confirmation in human-relevant systems.
Structural features within and around the oligopyrimidine-AUG tandem modulate the initiation efficiency of poliovirus RNA translation, demonstrating the functional and genetic plasticities of the poliovirus genome.
Gmyl et al. (1993) studied Poliovirus genetics. Engineered poliovirus RNA species with modified 5'-untranslated region was evaluated on Isolation of revertant clones and pattern of genetic changes. Transfection with large amounts of engineered quasi-infectious poliovirus RNAs yielded revertant clones with diverse genetic changes, highlighting the importance of an oligopyrimidine-AUG tandem.
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