Key result
Mutations in the 5' noncoding region of enterovirus RNA, specifically upstream of position 567, reduced translation initiation efficiency and resulted in a lower-virulence phenotype in suckling mice.
Population
HeLa S3 cell-free translation system and suckling mice infected with coxsackievirus B1 strain RNA transcripts
Comparison
Mutations and deletions in the 5' noncoding… vs Wild-type coxsackievirus B1 RNA
Design
Preclinical
Authors
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In vitro coxsackievirus B1 data should not change clinical practice; leaves open 5' NCR contributions to cardiotropism for further study.
Specific nucleotide sequences in the 5' noncoding region of enterovirus RNA are essential for translation initiation, and their deletion reduces viral virulence.
Iizuka et al. (1991) studied Enterovirus infection. Mutations in the 5' noncoding region of enterovirus RNA vs. Wild-type virus / unmodified RNA was evaluated on Efficiency of translation initiation and virulence. Mutations in the 5' noncoding region of enterovirus RNA, specifically upstream of position 567, reduced translation initiation efficiency and resulted in a lower-virulence phenotype in suckling mice.
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