Predictors of mortality in patients hospitalized for congestive heart failure with left ventricular ejection fraction ≥ 40%
Key result
Lower left ventricular end diastolic dimension (≤ 4.1 cm) independently predicted increased mortality (HR 1.73) in patients hospitalized for heart failure with LVEF ≥ 40%.
Authors
Discussion
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Implication
May aid risk stratification in HF with LVEF ≥40%; leaves open prospective validation before clinical use.
Study Design
Type
Cohort (n=191)
Multicenter
No
PICO
P
Population
191 patients hospitalized for decompensated heart failure with LVEF ≥ 40%, mean age 70 years and 60% female, followed for an average of 4.0 years.
E
Exposure / Comparator
LVEDD ≤ 4.1 cm vs LVEDD > 4.1 cm
O
Primary Outcome
All-cause mortality — HR 1.73 (1.13-2.65), p=0.011
Main Result
Hazard Ratio: 1.73 (95% CI 1.13–2.65)
p-value: p=0.011
Limitations
- Retrospective design
- Small study cohort
- Lacked detailed systematic examination of diastolic dysfunction
- Lacked biomarkers such as troponin and B-type natriuretic peptide level
- No data on revascularization during the index hospitalization
Cite This Study
Sherazi et al. (2015) conducted a cohort in Congestive heart failure with LVEF ≥ 40% (n=191). LVEDD ≤ 4.1 cm vs. LVEDD > 4.1 cm was evaluated on All-cause mortality (HR 1.73, 95% CI 1.13-2.65, p=0.011). Lower left ventricular end diastolic dimension (≤ 4.1 cm) independently predicted increased mortality (HR 1.73) in patients hospitalized for heart failure with LVEF ≥ 40%.