Key result
Fetuses with coarctation of the aorta had significantly reduced global circumferential strain compared to normal controls at first scan (18.50% vs 37.73%, P<0.001).
Why the study?
Abnormal aortic elastic properties are a major vasculopathy in coarctation of the aorta, but there were no reports evaluating aortic wall elastic characteristics in fetuses with the condition.
Are aortic elastic properties impaired in fetuses with coarctation of the aorta compared to normal controls?
Case-Control (n=112)
Are aortic elastic properties impaired in fetuses with coarctation of the aorta compared to normal controls?
Absolute Event Rate: 18.5% vs 37.73%
p-value: p=<0.001
Fetuses with coarctation of the aorta exhibit significantly impaired aortic elastic properties in utero, which correlate with diminished heart function and aortic isthmus size.
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Fetal CoA shows impaired ascending aortic elasticity linked to function; leaves open predictive value for later morbidity.
Xu et al. (2023) conducted a case-control in Coarctation of the aorta (n=112). Coarctation of the aorta vs. Normal controls was evaluated on Global circumferential strain at first scan (p=<0.001). Fetuses with coarctation of the aorta had significantly reduced global circumferential strain compared to normal controls at first scan (18.50% vs 37.73%, P<0.001).
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