Key result
Tissue factor, coagulation proteases, and protease-activated receptors contribute to heart hemostasis and pathological remodeling in myocardial infarction, viral myocarditis, and hypertension.
This review highlights the role of tissue factor, coagulation proteases, and protease-activated receptors in pathological heart remodelling associated with myocardial infarction, viral myocarditis, and hypertension.
May identify novel targets for cardiac remodeling; leaves open clinical translation pending interventional trials.
Tissue factor is the primary initiator of coagulation cascade and plays an essential role in haemostasis and thrombosis. In addition, tissue factor and coagulation proteases contribute to many cellular responses via activation of protease activated receptors. The heart is an organ with high levels of constitutive tissue factor expression. This review focuses on the role of tissue factor, coagulation proteases and protease activated receptors in heart haemostasis and the pathological heart remodelling associated with myocardial infarction, viral myocarditis and hypertension.
No takes yet. Share an insight, caveat, or question.
Antoniak et al. (2014) conducted a review in Pathological heart remodelling. Tissue factor, coagulation proteases and protease activated receptors was evaluated. Tissue factor, coagulation proteases, and protease-activated receptors contribute to heart hemostasis and pathological remodeling in myocardial infarction, viral myocarditis, and hypertension.