Key result
Metabolic syndrome in hypertensive patients was associated with significantly higher clinic (66 vs 58 mm Hg; P<0.00001) and 24-hour pulse pressures (51 vs 48 mm Hg; P=0.00001).
Why the study?
Does the presence of metabolic syndrome increase clinic and 24-h pulse pressures in patients with essential hypertension without diabetes mellitus?
Population
528 hypertensive subjects, aged 18 to 72 years, free of cardiovascular and renal diseases, without diabetes…
Comparison
Presence of metabolic syndrome vs Absence of metabolic syndrome
Design
Cross-sectional
Authors
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MS may raise pulse pressure in nondiabetic hypertensives; leaves open whether this alters risk stratification or requires targeted trials.
Cross-Sectional (n=528)
Does the presence of metabolic syndrome increase clinic and 24-h pulse pressures in patients with essential hypertension without diabetes mellitus?
Effect estimate: beta = 0.12
Absolute Event Rate: 66% vs 58%
p-value: p=<.00001
In non-diabetic patients with essential hypertension, the presence of metabolic syndrome is independently associated with elevated clinic and 24-hour pulse pressures, suggesting increased large artery stiffness.
Mulè et al. (2007) conducted a cross-sectional in Essential hypertension (n=528). Metabolic syndrome vs. Without metabolic syndrome was evaluated on Clinic pulse pressure (beta = 0.12, p=<.00001). Metabolic syndrome in hypertensive patients was associated with significantly higher clinic (66 vs 58 mm Hg; P<0.00001) and 24-hour pulse pressures (51 vs 48 mm Hg; P=0.00001).
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