Key result
Metabolic syndrome in essential hypertension patients was associated with a lower stroke volume index to pulse pressure ratio (0.65 vs 0.73 mm Hg; P=.0003).
Why the study?
Does the presence of metabolic syndrome reduce total arterial compliance in essential hypertension patients?
Cross-Sectional (n=528)
Does the presence of metabolic syndrome reduce total arterial compliance in essential hypertension patients?
Answers are grounded in this paper and cite their sources.
Metabolic syndrome is independently associated with reduced total arterial compliance in patients with essential hypertension, which may contribute to their increased cardiovascular risk.
The aim of the study was to cross-sectionally analyze, in a group of essential hypertension patients without diabetes mellitus, the influence of the metabolic syndrome (MS) on the stroke volume index to pulse pressure (SVi/PP) ratio, a measure of total arterial compliance. A total of 528 essential hypertension patients, aged 18 to 72 years, free from cardiovascular and renal disease (41% of whom had MS) were enrolled. All participants underwent routine blood chemistry, echocardiographic examination, and 3 blood pressure measurements at the end of echocardiographic examination. When compared with participants who did not have MS, hypertensive patients with MS exhibited lower SVi/PP ratio (0.65+/-0.22 vs 0.73+/-0.21 mm Hg; P=.0003). The independent association of MS with SVi/PP ratio (beta=0.10; P=.02) was confirmed in a multivariate regression model including age, sex, and other potential confounders as covariates. The authors' finding may help to explain the enhanced cardiovascular risk associated with MS.
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Mulè et al. (2007) conducted a cross-sectional in Essential hypertension (n=528). Metabolic syndrome vs. No metabolic syndrome was evaluated on Stroke volume index to pulse pressure (SVi/PP) ratio (beta=0.10, p=.0003). Metabolic syndrome in essential hypertension patients was associated with a lower stroke volume index to pulse pressure ratio (0.65 vs 0.73 mm Hg; P=.0003).
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