January 1, 2007Blood Pressure
Blood pressure control and response rates with zofenopril compared with amlodipine in hypertensive patients
Why the study?
Does zofenopril reduce blood pressure comparably to amlodipine in patients with mild to moderate hypertension?
Population
303 patients with mild to moderate hypertension, aged 18-75 years
Comparison
Zofenopril 30-60 mg oral once daily for 12 weeks vs Amlodipine 5-10 mg oral once daily for 12 weeks
Design
Other
Follow-up
12 weeks
Authors
Discussion
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Member takes
Implication
Zofenopril matches amlodipine for BP control in mild-moderate hypertension; confirms comparable short-term efficacy of ACEI versus CCB in this RCT.
Structured PICO
Does zofenopril reduce blood pressure comparably to amlodipine in patients with mild to moderate hypertension?
P
Population
303 patients with mild to moderate hypertension, aged 18-75 years
I
Intervention
Zofenopril 30-60 mg oral once daily for 12 weeks
C
Comparator
Amlodipine 5-10 mg oral once daily for 12 weeks
O
Outcome
Antihypertensive response (reduction in sitting systolic and diastolic blood pressure) and percentage of patients controlled at 12 weekssurrogate
Zofenopril and amlodipine provide comparable and substantial blood pressure reductions in patients with mild to moderate hypertension over 12 weeks.
Cite This Study
Csaba Farsang (2007) studied this question.