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April 24, 2021Anatolian Current Medical JournalOpen Access

The MHR values were found to be similar across healthy controls, normoweight PCOS, and overweight/obese PCOS groups (p=0.334).

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Why the study?

To examine and compare various variables, particularly the monocyte to high-density lipoprotein cholesterol ratio, between women with polycystic ovary syndrome and healthy controls.

Population

259 women aged 18-38, including 194 with PCOS and 65 without PCOS

Comparison

Women with PCOS vs healthy controls

Design

Retrospective single-centre database study

Authors

TGTuğba GÜRBÜZNONefise TANRIDAN OKÇUNGNur DOKUZEYLÜL GÜNGÖR

Discussion

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Overview

Similar MHR in PCOS and controls; leaves open its inflammatory role, requiring prospective studies before any clinical consideration.

Structured PICO

P
Population
259 women aged 18-38, including 194 with polycystic ovary syndrome (PCOS) and 65 healthy controls with normal menstrual cycles. Excluded: pregnant women, smokers, early menopause, lactation, and women with hypertension, diabetes mellitus, autoimmune diseases, chronic infectious diseases, or adrenal gland disease.
O
Outcome
Monocyte/HDL ratio (MHR)surrogate

Contrary to previous studies, the monocyte/HDL ratio was not significantly altered in women with PCOS and cannot be reliably used to quantify inflammation or lipid profile changes in this population.

Limitations

  • Retrospective design
  • Lack of patients' medication data
  • Acute infectious diseases could not be assessed
  • Older age of the control group

Cite This Study

GÜRBÜZ et al. (2021) studied this question.

synapsesocial.com/papers/6a6f8cd178a11c550e0945f1https://doi.org/10.38053/acmj.839213
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Monocyte high density lipoprotein ratio and neutrophil lymphocyte ratio a novel marker in polycystic ovary syndrome2022 · 1 citations
  2. 2Comparison of the different PCOS phenotypes based on monocyte to HDL cholesterol ratio2022 · 5 citations
  3. 3The Cardiovascular Risk of Young Women with Polycystic Ovary Syndrome: An Observational, Analytical, Prospective Case-Control Study2004 · 277 citations
  4. 4Heart Rate Variability and Its Relationship with Hormonal Changes in Normal and High BMI Women with Polycystic Ovarian Syndrome2024
  5. 5Elevated low-density lipoprotein-cholesterol in women with polycystic ovary syndrome1996 · 23 citations