Why the study?
Does captopril improve mood in depressed patients?
Does captopril improve mood in depressed patients?
Captopril may have mood-elevating effects in depressed patients, suggesting a potential role for ACE inhibitors in neuropsychiatric disorders.
Should not change depression management; leaves open whether ACE inhibitors merit controlled trials in mood disorders.
The use of captopril, an inhibitor of angiotensin-converting enzyme and enkephalinase, was associated with substantial mood elevation in three depressed patients. Substances that may alter neuropeptide synthesis or degradation warrant further investigation as therapeutic agents in certain neuropsychiatric disorders.
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Zubenko et al. (1984) studied this question.
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