Why the study?
Does captopril alter reflex control of heart rate through the removal of angiotensin II in normotensive subjects?
Population
Normotensive subjects (in vivo) and bovine erythrocytes (in vitro)
Comparison
Captopril, saralasin, and angiotensin II infusion vs Placebo
Design
Other
Authors
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May explain absent reflex tachycardia with ACE inhibitors via angiotensin II removal; challenges acetylcholinesterase hypothesis but leaves open clinical translation.
Does captopril alter reflex control of heart rate through the removal of angiotensin II in normotensive subjects?
The lack of reflex tachycardia with ACE inhibitors is likely due to the removal of angiotensin II rather than acetylcholinesterase inhibition.
Ajayi et al. (1985) studied this question.
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