Why the study?
Does aconitine modification have isoform-specific effects on the kinetics of human heart and rat skeletal muscle sodium channels?
Does aconitine modification have isoform-specific effects on the kinetics of human heart and rat skeletal muscle sodium channels?
Aconitine modification affects the inactivation of human heart and rat skeletal muscle sodium channels distinctly, highlighting an important role for external sodium ions in human heart channel inactivation.
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External sodium partially modulates aconitine effects on cardiac sodium channel inactivation; leaves open clinical relevance for human cardiotoxicity.
Sterling N. Wright (2002) studied this question.
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