Population
Spontaneously hypertensive rats and three strains of normotensive control rats
Comparison
Chemical stimulation with KCl, noradrenaline… vs Normotensive control rats
Design
Preclinical
Authors
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May indicate generalized smooth muscle Ca2+ dysregulation in hypertension models; leaves open human translation and should not change practice.
The study demonstrates altered sensitivity and calcium utilization in nonvascular smooth muscle of spontaneously hypertensive rats, suggesting a generalized genetic alteration in smooth muscle responsiveness.
Corbett et al. (1980) studied this question.
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