Reproducibility and clinical value of nocturnal hypotension
Why the study?
Does treatment-induced modification of day-night blood pressure difference predict the regression of left ventricular mass index in patients with essential hypertension and left ventricular hypertrophy?
Population
Patients with essential hypertension and echocardiographically detected left ventricular hypertrophy…
Comparison
Lisinopril or lisinopril plus… vs Pretreatment 4-week wash-out period and final…
Design
Cohort
Follow-up
12 months
Authors
Discussion
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Member takes
Implication
Day-night BP modification should not guide LVH regression assessment; leaves open whether circadian patterns add value beyond 24-hour averages in hypertension.
Structured PICO
Does treatment-induced modification of day-night blood pressure difference predict the regression of left ventricular mass index in patients with essential hypertension and left ventricular hypertrophy?
P
Population
Patients with essential hypertension and echocardiographically detected left ventricular hypertrophy involved in the SAMPLE study (n=180).
I
Intervention
Lisinopril or lisinopril plus hydrochlorothiazide for 12 months.
C
Comparator
Pretreatment 4-week wash-out period and final 4-week placebo period.
O
Outcome
Reproducibility of day-night blood pressure difference and its relationship to treatment-induced regression of left ventricular mass index.surrogate
Day-night blood pressure changes and dipper/non-dipper classifications are poorly reproducible over time and do not predict treatment-induced regression of left ventricular hypertrophy, limiting their clinical utility.
Cite This Study
Omboni et al. (1998) studied this question.