Why the study?
Do single intravenous doses of captopril affect blood pressure, heart rate, and humoral responses in normal volunteers?
Do single intravenous doses of captopril affect blood pressure, heart rate, and humoral responses in normal volunteers?
Single intravenous doses of captopril dose-dependently inhibit the renin-angiotensin system without acutely affecting blood pressure or heart rate in normal volunteers.
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Acute captopril safely suppresses RAS without hemodynamic effects in normals; extends mechanistic data for ACE inhibitor dosing studies.
The blood pressure, heart rate and humoral responses to single intravenous doses of the angiotensin converting enzyme inhibitor captopril were evaluated in 5 volunteers on a free salt intake. Each subject was given at one-week intervals a 1, 5 and 25 mg intravenous dose of captopril as well as the vehicle of captopril. The study was conducted in a single-blind fashion and the order of treatment phases was randomized. Captopril was found to inhibit the renin-angiotensin system in a dose-dependent fashion. A fall in circulating angiotensin II was observed with doses of 1 and 5 mg. Plasma angiotensin II was not detectable 15 min after the 25 mg dose. Acute inhibition of angiotensin converting enzyme with intravenous captopril had no effect on blood pressure and heart rate.
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Nussberger et al. (1987) studied this question.
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