Population
Pigs with pacing-induced dilated cardiomyopathy resulting in congestive heart failure and normal pigs.
Comparison
Volume loading and pericardiectomy, with rapid… vs Normal pigs; baseline conditions.
Design
Preclinical
Authors
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Altered systolic ventricular interactions in dilated cardiomyopathy warrant further study; leaves open translation to human pericardial and ventricular mechanics.
In a pig model of pacing-induced heart failure, dilated cardiomyopathy increases systolic but not diastolic ventricular interactions, while the pericardium primarily increases diastolic interactions.
Farrar et al. (1995) studied this question.
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