Antithrombin III Effects on the Production of Vasoactive Substances in Endotoxemic Rats.

Toshiaki Iba; Kunihiko Nagakari; Kengo Onodera; Akio Kidokoro; Yoichi Ohno; Yoshiaki Kaneshiro; Tadahisa Samejima

doi:10.3893/jjaam.10.177

January 1, 1999Nihon Kyukyu Igakukai Zasshi Journal of Japanese Association for Acute MedicineOpen Access

Antithrombin III Effects on the Production of Vasoactive Substances in Endotoxemic Rats.

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Why the study?

Does antithrombin III improve survival and modulate vasoactive substance production in endotoxemic rats?

Structured PICO

Does antithrombin III improve survival and modulate vasoactive substance production in endotoxemic rats?

P

Population

Wistar rats with endotoxemia induced by continuous intravenous administration of lipopolysaccharide (LPS) over 24 hours

I

Intervention

Antithrombin III (AT-III) 250 U/kg or 500 U/kg administered continuously intravenously over 24 hours

C

Comparator

Normal saline administered continuously intravenously over 24 hours

O

Outcome

Survival rate at the end of 24-hour administrationhard clinical

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Implication

High-dose antithrombin III significantly improves survival and stimulates PGI2 production in a rat model of endotoxemia, suggesting organ-protective effects beyond anticoagulation.

Abstract

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Cite This Study

Iba et al. (1999) studied this question.

synapsesocial.com/papers/6a730c5571b722800df5c787 https://doi.org/10.3893/jjaam.10.177

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Antithrombin III Effects on the Production of Vasoactive Substances in Endotoxemic Rats.

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Antithrombin III Effects on the Production of Vasoactive Substances in Endotoxemic Rats.

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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