Protective effects of antithrombin III on organ dysfunction induced by the continuous infusion of endotoxin in rats.

Toshiaki Iba; Yoshihiro Yagi; Akio Kidokoro; Yoichi Ohno; Hitoshi Tanaka; Yoshiaki Kaneshiro; Kenji Kaneko

doi:10.3893/jjaam.9.45

January 1, 1998Nihon Kyukyu Igakukai Zasshi Journal of Japanese Association for Acute MedicineOpen Access

Protective effects of antithrombin III on organ dysfunction induced by the continuous infusion of endotoxin in rats.

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Why the study?

Does antithrombin III prevent organ dysfunction in a rat model of continuous endotoxin infusion?

Structured PICO

Does antithrombin III prevent organ dysfunction in a rat model of continuous endotoxin infusion?

P

Population

Male Wistar rats weighing approximately 250g (n=21) subjected to continuous infusion of endotoxin (LPS 0.5 mg/kg over 24 hours).

I

Intervention

Antithrombin III (AT-III) administered as continuous infusion (20 U/kg/hr for 24h), bolus plus continuous infusion (500 U/kg bolus + 20 U/kg/hr for 24h), or combined with heparin (10 U/kg/hr heparin + 20 U/kg/hr AT-III for 24h).

C

Comparator

Saline continuous infusion for 24 hours simultaneously with LPS.

O

Outcome

Organ dysfunction and coagulation parameters (AT-III activity, fibrinogen, BUN, ALT, creatinine, total bilirubin, platelet count, WBC, D-dimer, and histological findings in liver and kidney) at 24 hours.surrogate

Antithrombin III administration improves coagulation abnormalities and prevents organ dysfunction in a rat model of continuous endotoxin infusion.

Limitations

Relatively large dose of AT-III used, which might have masked the effect of heparin
Platelet count decrease did not correlate with the degree of thrombus formation or organ dysfunction

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Implication

AT-III attenuates endotoxin-induced organ dysfunction in rats; leaves open translation to human sepsis.

Abstract

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Discussion

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Cite This Study

Iba et al. (1998) studied this question.

synapsesocial.com/papers/6a730c5971b722800df5c788 https://doi.org/10.3893/jjaam.9.45

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Protective effects of antithrombin III on organ dysfunction induced by the continuous infusion of endotoxin in rats.

Structured PICO

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Protective effects of antithrombin III on organ dysfunction induced by the continuous infusion of endotoxin in rats.

Structured PICO

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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