Why the study?
Does the combination of metoprolol and nifedipine improve blood pressure reduction at rest and during exercise in hypertensive males compared to either drug alone?
Does the combination of metoprolol and nifedipine improve blood pressure reduction at rest and during exercise in hypertensive males compared to either drug alone?
The combination of a calcium channel blocker (nifedipine) and a beta-blocker (metoprolol) safely potentiates blood pressure reduction at rest and during exercise in hypertensive patients.
May support beta-blocker–CCB combinations for BP control; leaves open need for outcome trials versus contemporary regimens.
The effects of metoprolol and/or nifedipine on blood pressure were studied in 12 hypertensive males at rest and during standardized exercise on an ergometer bicycle. Metoprolol (100 mg X 2) and nifedipine (10 mg X 3) gave similar blood pressure reductions both at rest and during exercise. When the drugs were combined, the antihypertensive effect was potentiated. The PQ interval was not affected during any treatment period. No adverse reactions to the combined treatment were noted. The combination of a calcium blocker with vasodilating properties with a beta-blocker, which reduces cardiac output, thus seems a logical and promising therapeutic approach in the treatment of hypertension.
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Ekelund et al. (1982) studied this question.
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