Why the study?
Peak VO2 on CPET predicts mortality and transplantation in severe HFrEF, but differences between treadmill and cycle CPET modalities needed evaluation.
Does treadmill CPET yield different peak VO2 and VE/VCO2 slopes compared to cycle ergometer CPET in males with severe HFrEF?
Does treadmill CPET yield different peak VO2 and VE/VCO2 slopes compared to cycle ergometer CPET in males with severe HFrEF?
In patients with severe HFrEF, treadmill CPET yields significantly higher peak VO2 compared to cycle ergometry, whereas the VE/VCO2 slope remains consistent across both modalities.
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Treadmill yields higher peak VO2 than cycle in severe HFrEF; leaves open modality-specific prognostic thresholds pending larger validation.
Mazaheri et al. (2021) studied this question.
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