September 17, 1990FEBS LettersOpen Access

Molecular cloning of human cardiac troponin I using polymerase chain reaction

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Population

Human cardiac cDNA library and human development samples

Design

Preclinical

Authors

WVWilliam VallinsUniversity of Leeds NBNigel J. BrandCentre National de la Recherche Scientifique NDNina DabhadeImperial College London

Discussion

Member takes

Implication

No immediate clinical impact; extends molecular tools for troponin I biomarker and developmental studies.

Structured PICO

Population

Human cardiac cDNA library and human development samples

Intervention

Polymerase chain reaction (PCR) using degenerate oligonucleotides

Outcome

Cloning and complete amino acid sequence of human cardiac troponin I

This basic science study describes the initial molecular cloning and sequencing of human cardiac troponin I, a critical step in its eventual development as a key cardiac biomarker.

Cite This Study

Vallins et al. (1990) studied this question.

synapsesocial.com/papers/6a751f8601b447f0dadc0324 https://doi.org/10.1016/0014-5793(90)81234-f

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Molecular cloning of human cardiac troponin I using polymerase chain reaction

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Molecular cloning of human cardiac troponin I using polymerase chain reaction

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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