Why the study?
Does aliskiren compared to hydrochlorothiazide reduce muscle sympathetic nerve activity in elderly patients with stage-I hypertension?
Population
14 elderly patients with stage-I hypertension, mean age 66 ± 5 years
Comparison
Aliskiren (direct renin inhibitor) for 6 months vs Hydrochlorothiazide (diuretic) for 6 months
Design
Cohort
Follow-up
6 months
Authors
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Aliskiren may avoid diuretic-related sympathetic activation in elderly hypertension; hypothesis-generating and should not yet change practice.
Does aliskiren compared to hydrochlorothiazide reduce muscle sympathetic nerve activity in elderly patients with stage-I hypertension?
In elderly hypertensive patients, chronic renin inhibition with aliskiren lowers blood pressure without causing the sympathetic activation seen with diuresis.
Okada et al. (2013) studied this question.
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