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July 1, 1973Radiology

Experimental Myocardial Imaging with131I-Labeled Oleic Acid

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Why the study?

Does intravenous 131I-labeled oleic acid enable successful myocardial imaging in animal models?

Population

Rabbits and dogs (including dogs with experimental coronary embolization with metallic Hg)

Comparison

Intravenous administration of 131I-labeled oleic… vs Before and after experimental coronary…

Design

Preclinical

Authors

FBFrederick J. BonteParkland Memorial HospitalKGKenneth D. GrahamThe University of Texas Southwestern Medical CenterJMJohn G. MooreManchester Royal Infirmary

Discussion

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Implication

Caution against clinical use; leaves open human translation of 131I-oleic acid myocardial imaging.

Structured PICO

Does intravenous 131I-labeled oleic acid enable successful myocardial imaging in animal models?

P
Population
Rabbits and dogs (including dogs with experimental coronary embolization with metallic Hg)
I
Intervention
Intravenous administration of 131I-labeled oleic acid
C
Comparator
Before and after experimental coronary embolization (in dogs)
O
Outcome
Distribution of 131I-labeled oleic acid and successful myocardial imagingsurrogate

131I-labeled oleic acid shows feasibility as a radiotracer for myocardial imaging in preclinical animal models.

Cite This Study

Bonte et al. (1973) studied this question.

synapsesocial.com/papers/6a75efe2f56d87d9178b7539https://doi.org/10.1148/108.1.195
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Fatty acid analogue accumulation: a marker of myocyte viability in ischemic-reperfused myocardium.1988 · 67 citations
  2. 2External assessment of myocardial metabolism with [11C]palmitate in rabbit hearts1979 · 45 citations
  3. 3Use of Radioiodinated Fatty Acid for Photoscans of the Heart1965 · 138 citations
  4. 4Early imaging of experimental myocardial infarction by intracoronary administraion of 131I-labelled anticardiac myosin (Fab')2 fragments.1978 · 63 citations
  5. 5An experimental model of hypoxia on isolated rat heart in recirculating system: study of fatty acid metabolism with an iodinated fatty acid1993 · 3 citations