Why the study?
Does low-dose amiodarone therapy maintain sinus rhythm and prevent recurrence of atrial fibrillation or flutter in Japanese patients with heart failure?
Does low-dose amiodarone therapy maintain sinus rhythm and prevent recurrence of atrial fibrillation or flutter in Japanese patients with heart failure?
Low-dose amiodarone is moderately effective for maintaining sinus rhythm over 5 years in Japanese patients with heart failure and AF/flutter, though 16% required discontinuation due to adverse effects.
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May support low-dose amiodarone for sinus rhythm in Japanese HF-AF; hypothesis-generating and requires RCTs before practice change.
Shiga et al. (2002) studied this question.
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