September 1, 2001Hypertension

Enhanced Interaction Between Renovascular α₂-Adrenoceptors and Angiotensin II Receptors in Genetic Hypertension

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Structured PICO

Population

Spontaneously hypertensive rats (SHR) (adrenalectomized, renal-denervated, captopril-pretreated), normotensive Wistar-Kyoto rats, uninephrectomized normotensive Sprague-Dawley rats, and Sprague-Dawley rats with nongenetic hypertension (DOCA-salt).

Intervention

Intrarenal infusions of Angiotensin II in the presence of coactivation of alpha2-adrenoceptors with UK 14,304.

Comparator

Intrarenal infusions of Angiotensin II in the absence of UK 14,304, and responses in normotensive or acquired hypertension models.

Outcome

Reductions in renal blood flow and increases in renovascular resistance.surrogate

In genetic hypertension, there is an enhanced cross-talk between the Gi signal transduction pathway and pathways activated by Angiotensin II and vasopressin involving phospholipase C and/or D.

Discussion

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Implication

Suggests Gi-PLC cross-talk in genetic hypertension models; leaves open relevance to human essential hypertension.

Cite This Study

Jackson et al. (2001) studied this question.

synapsesocial.com/papers/6a76517270b84e52bb88016d https://doi.org/10.1161/01.hyp.38.3.353

Topics

Hypertension management

View Full Paper

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Enhanced Interaction Between Renovascular α₂-Adrenoceptors and Angiotensin II Receptors in Genetic Hypertension

Structured PICO

Discussion

Implication

Cite This Study

Topics

Enhanced Interaction Between Renovascular α₂-Adrenoceptors and Angiotensin II Receptors in Genetic Hypertension

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider