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May 1, 1957Circulation Research

Effect of Plethora and Hemorrhage on Left Ventricular Volume and Pressure

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Why the study?

Does plethora and hemorrhage alter left ventricular volume and pressure in closed-chest dogs?

Population

closed-chest dog model

Design

Preclinical

Authors

JHJ. P. HoltUniversity of Wisconsin–MadisonJAJordan J. AllensworthMedical University of South CarolinaJDJohn N. DianaJoint Replacement Institute

Discussion

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Overview

May inform experimental volume studies in closed-chest models; leaves open translation to human hemodynamics.

Structured PICO

Does plethora and hemorrhage alter left ventricular volume and pressure in closed-chest dogs?

P
Population
closed-chest dog model
I
Intervention
plethora and hemorrhage
O
Outcome
end-diastolic volume (EDV) and end-systolic volume (ESV) of the left ventriclesurrogate

Demonstrates the physiological relationship between blood volume changes (plethora and hemorrhage) and left ventricular volumes and pressures in a closed-chest dog model.

Cite This Study

Holt et al. (1957) studied this question.

synapsesocial.com/papers/6a77f5d66789de8d0af78abchttps://doi.org/10.1161/01.res.5.3.273
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The effect of pericardium on the end-systolic pressure-segment length relationship in canine left ventricle in acute volume overload.1983 · 19 citations
  2. 2Right and left ventricular pressure-volume response to elevated pericardial pressure.1986 · 15 citations
  3. 3Effects of increased afterload on left ventricular function in closed-chest dogs1990 · 28 citations
  4. 4Ventricular diastolic pressure-volume relations and the pericardium. Effects of changes in blood volume and pericardial effusion in dogs.1981 · 64 citations
  5. 5Right and left ventricular volumes and function after acute pulmonary hypertension in intact dogs1995 · 21 citations