Why the study?
The effects of cardiac contractility modulation therapy on myocardial mechano-energetic efficiency and global longitudinal strain in patients with HFrEF are unknown.
Does cardiac contractility modulation therapy improve left ventricular global longitudinal strain and myocardial mechano-energetic efficiency in patients with HFrEF?
Population
25 patients with HFrEF who received an Optimizer Smart implant
Comparison
Six months after CCM therapy vs 24 h before implant
Design
Single-arm prospective study
Follow-up
Six months
Authors
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CCM may enhance efficiency in HFrEF; hypothesis-generating and requires larger randomized confirmation before practice change.
Does cardiac contractility modulation therapy improve left ventricular global longitudinal strain and myocardial mechano-energetic efficiency in patients with HFrEF?
Cardiac contractility modulation therapy improves left ventricular performance, including ejection fraction, global longitudinal strain, and mechano-energetic efficiency in patients with HFrEF.
Masarone et al. (2022) studied this question.
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