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July 20, 2022European Journal of Heart FailureOpen Access

Cardiac contractility modulation therapy improves health status in patients with heart failure with preserved ejection fraction: a pilot study ( CCM‐HFpEF )

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Why the study?

This pilot study aimed to assess the potential benefits of cardiac contractility modulation (CCM) in patients with heart failure with preserved ejection fraction (HFpEF).

Does cardiac contractility modulation therapy improve health status in patients with heart failure with preserved ejection fraction?

Population

47 patients with HFpEF and NYHA class II or III

Comparison

CCM therapy device implantation (single-arm)

Design

Prospective, multicentre, single-arm pilot study

Follow-up

24 weeks

Authors

CLCecilia LindeMGMarcin GrabowskiPPPiotr Ponikowski

Discussion

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Overview

May support CCM investigation in HFpEF; leaves open efficacy pending randomized trials.

Structured PICO

Does cardiac contractility modulation therapy improve health status in patients with heart failure with preserved ejection fraction?

P
Population
47 patients with heart failure with preserved ejection fraction (HFpEF) and NYHA class II or III, mean age 74.3, 70.2% female.
I
Intervention
Cardiac contractility modulation (CCM) therapy device implantation.
O
Outcome
Mean change in the Kansas City Cardiomyopathy Questionnaire (KCCQ) overall summary score at 24 weeks.patient reported

Cardiac contractility modulation therapy significantly improved health status (KCCQ score) in patients with HFpEF over 24 weeks with a favorable safety profile.

Cite This Study

Linde et al. (2022) studied this question.

synapsesocial.com/papers/6a716e18439bab0cabc392f4https://doi.org/10.1002/ejhf.2619
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1USE OF CARDIAC CONTRACTILITY MODULATION: OUR EXPERIENCE2024
  2. 2Cardiac contractility modulation therapy in elderly patients with chronic heart failure: results of the 12-month follow-up2021 · 1 citations
  3. 3Clinical Effects of Cardiac Contractility Modulation in Heart Failure with Mildly Reduced Systolic Function2020 · 15 citations
  4. 4QUALITY OF LIFE IMPROVEMENT AND REDUCTION IN HOSPITALIZATIONS IN PATIENTS WITH HEART FAILURE UNDERGOING CARDIAC CONTRACTILITY MODULATION (CCM) THERAPY: A SINGLE–CENTER EXPERIENCE2026
  5. 5Cardiac Contractility Modulation Therapy: Should We Be Aiming Higher for Patients With Moderately Severe Heart Failure?2022