Why the study?
Is ADP-induced platelet adhesiveness increased in patients with diabetes mellitus compared to healthy controls?
Is ADP-induced platelet adhesiveness increased in patients with diabetes mellitus compared to healthy controls?
Platelet adhesiveness is increased in patients with diabetes mellitus, particularly those on insulin and with more complications, suggesting a pro-thrombotic state.
Answers are grounded in this paper and cite their sources.
May signal heightened thrombotic risk in insulin-treated diabetes; leaves open causal role and therapeutic targeting.
The ADP‐induced platelet adhesiveness in 79 patients with diabetes mellitus and 70 healthy controls has been investigated. The mean platelet adhesiveness in the control group was 38% (S.D. 16.7), in patients on insulin 53% (S.D. 15.9), and in patients without insulin 44% (S.D. 13.9). In the group of insulin‐treated patients, the mean platelet adhesiveness increased significantly with the number of complications. No correlation between platelet adhesiveness and total cholesterol, blood sugar or dosage of insulin was found.
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A. J. Hellem (1971) studied this question.
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