September 27, 2017American Journal of HypertensionOpen Access

Increasing SBP and widening PP change were associated with higher odds of rapid kidney function decline compared with stable groups (OR 1.7, 95% CI 1.3-2.4 for SBP; OR 1.4, 95% CI 1.1-1.9 for PP).

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Why the study?

Does increasing systolic blood pressure or widening pulse pressure over time increase the risk of rapid kidney function decline in adults without chronic kidney disease?

Population

3,920 participants in the Multi-Ethnic Study of Atherosclerosis without chronic kidney disease who had ≥2 BP…

Comparison

Increasing systolic blood pressure or widening… vs Stable SBP or PP over 5 years

Design

Cohort

Follow-up

10 years (5 years for BP change, 5 years for eGFR change)

Authors

GJGregory Judson ARAnna D. Rubinsky MSMichael G. Shlipak

Discussion

Member takes

Overview

BP trajectory monitoring may flag early renal risk; leaves open whether targeting variability slows decline in preserved eGFR.

Structured PICO

Does increasing systolic blood pressure or widening pulse pressure over time increase the risk of rapid kidney function decline in adults without chronic kidney disease?

Population

3,920 participants in the Multi-Ethnic Study of Atherosclerosis (MESA) without chronic kidney disease (eGFR >60 ml/min/1.73 m2) who had ≥2 BP measurements during the first 5 years and eGFR measurements at both year 5 and 10, median age 59.

Intervention

Increasing systolic blood pressure (SBP) or widening pulse pressure (PP) over 5 years (top 20% of change distribution)

Comparator

Stable SBP or PP over 5 years (middle 21-79% of change distribution)

Outcome

Rapid kidney function decline (>30% decrease in eGFR from year 5 to 10)surrogate

Increasing systolic blood pressure and widening pulse pressure over time are associated with accelerated kidney function decline in adults without baseline chronic kidney disease, even at levels below established hypertension thresholds.

Cite This Study

Judson et al. (2017) studied this question.

synapsesocial.com/papers/6a7aad321b9920df6d895e30 https://doi.org/10.1093/ajh/hpx177

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September 27, 2017American Journal of HypertensionOpen Access

Increasing SBP and widening PP change were associated with higher odds of rapid kidney function decline compared with stable groups (OR 1.7, 95% CI 1.3-2.4 for SBP; OR 1.4, 95% CI 1.1-1.9 for PP).

View Full Paper

Ask AI

Bookmark

Why the study?

Does increasing systolic blood pressure or widening pulse pressure over time increase the risk of rapid kidney function decline in adults without chronic kidney disease?

Population

3,920 participants in the Multi-Ethnic Study of Atherosclerosis without chronic kidney disease who had ≥2 BP…

Comparison

Increasing systolic blood pressure or widening… vs Stable SBP or PP over 5 years

Design

Cohort

Follow-up

10 years (5 years for BP change, 5 years for eGFR change)

Authors

GJGregory Judson ARAnna D. Rubinsky MSMichael G. Shlipak

Discussion

Member takes

Overview

BP trajectory monitoring may flag early renal risk; leaves open whether targeting variability slows decline in preserved eGFR.

Structured PICO

Does increasing systolic blood pressure or widening pulse pressure over time increase the risk of rapid kidney function decline in adults without chronic kidney disease?

Population

Intervention

Increasing systolic blood pressure (SBP) or widening pulse pressure (PP) over 5 years (top 20% of change distribution)

Comparator

Stable SBP or PP over 5 years (middle 21-79% of change distribution)

Outcome

Rapid kidney function decline (>30% decrease in eGFR from year 5 to 10)surrogate

Cite This Study

Judson et al. (2017) studied this question.

synapsesocial.com/papers/6a7aad321b9920df6d895e30 https://doi.org/10.1093/ajh/hpx177

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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