Why the study?
The association between blood pressure and kidney function among middle-aged and older general populations without hypertension remains unclear.
Do high pulse pressure and abnormal systolic blood pressure increase the risk of rapid eGFR decline in a middle-aged and older general population without hypertension?
Population
4,534 participants aged ≥ 45 years without pre-existing hypertension in China
Comparison
Categories and combinations of systolic blood pressure, diastolic blood pressure, and pulse pressure
Design
Longitudinal cohort study
Key result
High pulse pressure (≥ 60 mmHg) significantly increased the risk of rapid decline in kidney function (OR 1.34) among middle-aged and older adults without pre-existing hypertension.
Authors
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May support pulse pressure assessment for kidney risk in normotensives; hypothesis-generating and should not yet change practice.
Cohort (n=4,534)
Yes
Do high pulse pressure and abnormal systolic blood pressure increase the risk of rapid eGFR decline in a middle-aged and older general population without hypertension?
Odds Ratio: 1.34 (95% CI 1.02–1.75)
Absolute Event Rate: 19.3% vs 14.9%
p-value: p=0.036
Both high pulse pressure and abnormal systolic blood pressure (either <120 or 130-139 mmHg) are associated with an increased risk of rapid kidney function decline in middle-aged and older adults without hypertension.
Wang et al. (2021) conducted a cohort in Rapid decline of kidney function (n=4,534). High pulse pressure (≥ 60 mmHg) vs. Normal pulse pressure (< 60 mmHg) was evaluated on Rapid decline of estimated glomerular filtration rate (eGFR decline ≥ 4 ml/min/1.73 m2/year) (OR 1.34, 95% CI 1.02-1.75, p=0.036). High pulse pressure (≥ 60 mmHg) significantly increased the risk of rapid decline in kidney function (OR 1.34) among middle-aged and older adults without pre-existing hypertension.
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