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August 1, 2020Clinical Interventions in AgingOpen Access

Each 10 mmHg rise in SBP was associated with a 34% increase in RKFD risk (adjusted HR: 1.34, 95% CI: 1.05-1.71, p=0.02).

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Why the study?

Blood pressure has been related to rapid kidney function decline, but studies examining this relationship in populations of advanced age are lacking.

Is higher blood pressure associated with rapid kidney function decline in a very elderly hypertensive Chinese population?

Population

284 hypertensive Chinese individuals over age 80

Comparison

Levels of SBP, DBP, and PP

Design

Cohort study

Follow-up

Median 3.3 years

Authors

KBKunhao BaiRCRui ChenFLFanghong Lu

Discussion

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Member takes

Overview

May warrant closer SBP monitoring in very elderly Chinese hypertensives; leaves open whether lowering SBP slows RKFD.

Structured PICO

Is higher blood pressure associated with rapid kidney function decline in a very elderly hypertensive Chinese population?

P
Population
284 hypertensive Chinese individuals over the age of 80 (systolic BP 160-200 mmHg; diastolic BP < 110 mmHg)
I
Intervention
Systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse pressure (PP) levels (exposure)
O
Outcome
Rapid kidney function decline (RKFD), defined as a decline in estimated glomerular filtration rate (eGFR) > 5mL/min per 1.73 m2 per year during follow-upsurrogate

In very elderly Chinese patients with hypertension, higher systolic blood pressure is significantly associated with an increased risk of rapid kidney function decline.

Cite This Study

Bai et al. (2020) studied this question.

synapsesocial.com/papers/6a8a4afa788d49930fcbf7b0https://doi.org/10.2147/cia.s255640
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