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September 24, 2014Journal of Hypertension

There was a dose-response association between baseline SBP/DBP and annual eGFR decline (P for trend <0.001), with the highest risk of rapid eGFR decline in men with baseline eGFR <110 and SBP >140 mm Hg (OR 2.9, 95% CI 1.6-5.1).

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Why the study?

Does elevated baseline blood pressure accelerate renal function decline in middle-aged adults?

Population

2383 rural Chinese men and women aged 40-60 years

Comparison

Elevated baseline blood pressure (SBP/DBP) vs Lower baseline blood pressure levels

Design

Cohort

Follow-up

7-year

Authors

QWQin WangDXDi XieXXXin Xu

Discussion

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Member takes

Overview

May warrant closer renal monitoring in middle-aged men with hypertension; leaves open whether BP reduction slows eGFR decline.

Structured PICO

Does elevated baseline blood pressure accelerate renal function decline in middle-aged adults?

P
Population
2383 rural Chinese men and women aged 40-60 years
I
Intervention
Elevated baseline blood pressure (SBP/DBP)
C
Comparator
Lower baseline blood pressure levels
O
Outcome
Annual estimated glomerular filtration rate (eGFR) change and rapid eGFR decline (>3 ml/min per 1.73 m2 per year)surrogate

Elevated baseline systolic and diastolic blood pressure are associated with a dose-dependent decline in renal function in middle-aged adults, particularly in men with lower baseline eGFR.

Cite This Study

Wang et al. (2014) studied this question.

synapsesocial.com/papers/6a8a4afa788d49930fcbf7b7https://doi.org/10.1097/hjh.0000000000000360
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Blood Pressure is Associated with Rapid Kidney Function Decline in a Very Elderly Hypertensive Chinese Population2020 · 8 citations
  2. 2Age and estimated glomerular filtration rate in Chinese older adults: a cohort study from 2014 to 20202024 · 2 citations
  3. 3Longitudinal Blood Pressure Changes and Kidney Function Decline in Persons Without Chronic Kidney Disease: Findings From the MESA Study2017 · 17 citations
  4. 4The correlation between blood pressure and kidney function decline in older people: a registry-based cohort study2015 · 38 citations
  5. 5Association between pulse pressure, systolic blood pressure and the risk of rapid decline of kidney function among general population without hypertension: results from the China health and retirement longitudinal study (CHARLS)2021 · 22 citations