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February 1, 1996Journal of VirologyOpen Access

Infectious RNA transcribed from an engineered full-length cDNA template of the genome of a pestivirus

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Population

In vitro model of classical swine fever virus (C strain)

Comparison

Engineered full-length cDNA template and hybrid… vs Native C-strain virus and non-infectious template

Design

Preclinical

Authors

RMR.J.M. MoormannRGRené G. P. van GennipGMG K Miedema

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Overview

Provides reverse genetics platform for CSFV; leaves open utility for marker vaccines pending in vivo validation.

Structured PICO

P
Population
In vitro model of classical swine fever virus (C strain)
I
Intervention
Engineered full-length cDNA template (pPRKflc-133) and hybrid virus (FLc-h6)
C
Comparator
Native C-strain virus and non-infectious template (pPRKflc-113)
O
Outcome
Infectivity of in vitro transcripts and viral growthsurrogate

The development of an infectious full-length cDNA template for classical swine fever virus provides a tool for creating marker vaccines and studying viral pathogenesis.

Cite This Study

Moormann et al. (1996) studied this question.

synapsesocial.com/papers/6a7c00461f8f1eb7b8ed4e34https://doi.org/10.1128/jvi.70.2.763-770.1996
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  1. 1Antigenic structure of envelope glycoprotein E1 of hog cholera virus1994 · 136 citations
  2. 2Infectious Japanese encephalitis virus RNA can be synthesized from in vitro-ligated cDNA templates1992 · 151 citations
  3. 3Epitope mapping of envelope glycoprotein E1 of hog cholera virus strain Brescia1993 · 89 citations
  4. 4Infectious RNA transcribed from stably cloned full-length cDNA of dengue type 4 virus.1991 · 230 citations